Generative AI for vision-preservation
RETICAD


Exam revealing retinal leakage that, till now, required an injection of a dye into the patient’s arm
Routine, injection-free retina exam
Our mission is to prevent blindness caused by delayed treatment of retinal leakage.
​
350 million people have retinal disease caused by aging or diabetes.
At some point in time, the disease makes the blood vessels in the retina leaky, causing subtle, unnoticeable damage that eventually leads to vision loss.
Detecting leakage before it damages the retina is challenging because it requires injecting dye into the patient’s arm.
The risks and complexities associated with dye injections have made this test underused, resulting in delayed detection and treatment of leakage.
Our generative AI makes this test injection-free and widely accessible, allowing early leakage detection and preventive treatment to preserve vision.
2
The AI transforms the injection-free image into injection-based images that show retinal leakage (called Fluoresceine Angiography)

1
A routine retinal image is captured without dye injection in a stnadard procedure called a fundus exam


PUBLICATIONS
-
Quantitative Fluorescein Angiography Biomarkers in Diabetic Macular Edema.
Retina. 2025.
-
Dye-free fluorescein angiography and retinal leakage analysis.
48th Annual Meeting of the Macula Society. 2025. Charlotte Harbor, FL, USA.
-
RETICAD: A tool for generating dye-free fluorescein angiography and quantifying retinal disease activity.
ARVO annual meeting. 2024. Seattle,WA, USA.
-
RETICAD: Quantitative Analysis of Treatment Response in Eyes with Retinal Vein Occlusion.
ARVO annual meeting. 2024. Seattle,WA, USA.
-
Prediction of Visual Acuity Response to Ranibizumab in Age-Related Macular Degeneration Using Artificial Intelligence-Based Analysis of Fluorescein Angiography.
ARVO annual meeting. 2024. Seattle,WA, USA.
-
RETICAD: an artificial intelligence (AI) tool for generating dye free fluorescein angiography.
47th Annual Meeting of the Macula Society. 2024. Palm Springs, CA, USA.
-
Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy.
Prog Retin Eye Res. 2024
-
Association of Intravenous Fluorescein Angiography and Adaptive Optics Imaging in Diabetic Retinopathy.
Retina. 2024.
-
Artificial intelligence-based extraction of quantitative ultra-widefield fluorescein angiography parameters in retinal vein occlusion.
Can J Ophthalmol. 2024
-
Artificial Intelligence-Enhanced Analysis of Retinal Vasculature in Age-Related Macular Degeneration.
Retina. 2024.
-
An Algorithm for Detecting Leaky Retinal Microaneurysms.
ARVO annual meeting. 2023. New Orleans, LA, USA.
-
An Automated Tool for Quantitative Assessment of Retinal Vasculopathy.
ARVO annual meeting. 2023. New Orleans, LA, USA.
-
Angiographic evidence of proliferative retinopathy predicts neuropsychiatric morbidity in diabetic patients.
Psychoneuroendocrinology. 2016.
-
Retinal Fluorescent Angiography Predicts Blood-Brain Barrier Damage and Neuropsychiatric Morbidity in Diabetic Patients.
Mediterranean Neuroscience Society 5th Meeting. 2015. Santa Margherita di Pula, Sardinia, Italy.
-
Novel fluorescein angiography-based computer-aided algorithm for assessment of retinal vessel permeability.
PLoS One. 2013.